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Pound for pound, fat contains more energy than any other nutrient. So it’s perhaps not surprising that certain cancer cells show a clear preference for growth in fatty tissues.

一磅換一磅，脂肪所含的能量比任何其他營養素都要多。因此，某些癌細胞明顯偏好生長在脂肪含量高的組織中也并不奇怪。

According to a new study by researchers at Memorial Sloan Kettering (MSK), melanomas prefer to grow near adipose (fat) tissue. The team, led by Richard White, a physician-scientist in the Cancer Biology and Genetics Program at SKI, showed that melanomas actively take in lipids if given the chance, and they tend to migrate toward tissues rich in fat cells.

紀念斯隆凱特林學院(MSK)研究人員的一項新研究表明，黑色素瘤更喜歡在脂肪組織附近生長。由理查德.懷特領導的研究小組發現，如果時機合適，黑色素瘤會主動吸收脂質，而且更容易向富含脂肪細胞的組織轉移。

“This is the seed-and-soil hypothesis,” White says. “Tumor cells like to go to places where there is fertile soil. Based on our results, we think that adipose tissue can be very fertile soil for melanoma.”

“這是種子-土壤假說”懷特說。“腫瘤細胞喜歡去有肥沃土壤的地方。我們的研究結果顯示，脂肪組織可以成為黑色素瘤生長的肥沃土壤�！�

That the presence of fat cells could help some cancer cells grow and spread sheds new light on the deepening connection between obesity and cancer and could offer a new avenue for treatment. For certain cancers, cutting off the fat supply could be a means of fighting the disease.

脂肪細胞的存在可以幫助一些癌細胞生長和擴散，這使人們對肥胖和癌癥之間日益加深的關系有了新的認識，且為治療癌癥提供了新途徑。對于某些癌癥，切斷脂肪供應可能不失為對抗疾病的一種手段。

OBESITY AND CANCER

肥胖和癌癥

Researchers have found that obesity is a significant risk factor for cancer and they are still untangling the relationship. While White’s study doesn’t directly address the matter, he says it does show a concrete link between lipids and cancer growth. In that sense, it adds one piece to what is likely a very large puzzle.

研究人員發現，肥胖是患癌癥的一大危險因素，他們仍在研究這一關系。雖然懷特的研究沒有直接解決這個問題，但他說，研究確實顯示了脂質與癌癥生長之間的具體聯系。從這個意義上說，癌癥這一大難題的一小部分得到了解決。

Whether altering one’s diet to consume less fats might forestall melanoma progression is another open question, one the team is interested in exploring further.

改變飲食結構以減少脂肪攝入是否能預防黑素瘤的惡化，這是另一個有待解決的問題，該研究小組有興趣進一步探索這一問題。

The study shows the utility of model systems like zebrafish for studying cancer, and the advantage of a place like MSK, where basic scientists and clinicians can easily collaborate.

這項研究顯示了像斑馬魚這樣的生物模型系統在研究癌癥方面的效用，以及在MSK這種地方的優勢，在那里基礎科學家和臨床醫生很容易就可以進行合作。

“We started this in the zebrafish and were able to take it all the way through to human tissues,” White says. “It would have been tough to pull this off at another institution.”

懷特說:“我們從斑馬魚身上開始做這個實驗，并把它帶到人體組織中�！薄耙诹硪患覚C構做到這一點很難�！�

本文來自：逍遙右腦記憶 http://www.lg566.com/chuzhong/1164911.html

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研究發現：脂肪細胞可助長癌細胞增長

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